基于FastICA与ICEEMDAN的人脸视频心率检测

现有的非接触式心率检测方法存在噪声干扰、准确率低等问题。针对这些问题,提出一种基于FastICA与改进的自适应噪声完全集合经验模态分解(ICEEMDAN)相结合的算法,采用人脸视频进行心率检测。用摄像头采集人脸视频,并从视频中提取R、G、B通道源信号,即皮肤颜色变化信号,分别求出RGB这3个颜色通道的像素平均值;然后利用 FastICA对RGB这3组像素平均值进行解混,得到3组独立源信号,再用ICEEMDAN将其中一组独立源信号进行模态分解,并选取合适频段内的固有模式函数(IMF)估计心率的信号,最后用频谱分析计算得到心率。设计实验对8名人员进行了人脸视频检测,将检测结果与多参数监护仪进行对比分析。实验结果表明,该方法与多参数监护仪测量结果的平均误差与均方根误差均小于1 beat/min,因此基于FastICA与ICEEMDAN的人脸视频心率检测对人体心率检测具有良好的稳定性和准确性。     

Forecasting demand for Hib-containing vaccine in the world's poorest countries: A 4-year prospective experience

This article analyzes the performance of a Hib vaccine demand forecast developed in 2003 for 68 GAVI-supported countries between 2004 and 2007. During that period of time, corresponding to an acceleration of Hib vaccine uptake, several groups of countries were identified based on the stage of their decision-making process, perception of Hib disease burden and programme performance. Better forecast accuracy was obtained for countries having already introduced the vaccine or that were about to do so. The ability to anticipate global needs in terms of vaccine volumes was highly dependant on the actual year of introduction of a small number of very large countries.     

基于主成分分析的生活垃圾产生量模型研究

分析了城市生活垃圾产生量的影响因素,从中选取了6项主要影响因素,研究了它们与城市生活垃圾产生量之间的关系;根据合肥市城市生活垃圾产生量的统计数据,运用主成分分析法对6项指标进行了综合分析,并研究其贡献率,提取出综合因子;针对城市生活垃圾产生量的增长特点,运用一元线性回归方法对综合因子进行拟合,建立了基于主成分分析的城市生活垃圾产生量模型;对合肥市2010年及2015年的生活垃圾产生量进行了预测。     

Rapid equilibrium sampling initiated from nonequilibrium data

Simulating the conformational dynamics of biomolecules is extremely difficult due to the rugged nature of their free energy landscapes and multiple long-lived, or metastable, states. Generalized ensemble (GE) algorithms, which have become popular in recent years, attempt to facilitate crossing between states at low temperatures by inducing a random walk in temperature space. Enthalpic barriers may be crossed more easily at high temperatures; however, entropic barriers will become more significant. This poses a problem because the dominant barriers to conformational change are entropic for many biological systems, such as the short RNA hairpin studied here. We present a new efficient algorithm for conformational sampling, called the adaptive seeding method (ASM), which uses nonequilibrium GE simulations to identify the metastable states, and seeds short simulations at constant temperature from each of them to quantitatively determine their equilibrium populations. Thus, the ASM takes advantage of the broad sampling possible with GE algorithms but generally crosses entropic barriers more efficiently during the seeding simulations at low temperature. We show that only local equilibrium is necessary for ASM, so very short seeding simulations may be used. Moreover, the ASM may be used to recover equilibrium properties from existing datasets that failed to converge, and is well suited to running on modern computer clusters.     

北京市建筑垃圾产生量预测及处置设施建设分布研究

利用SPSS软件,通过选取北京市GDP、商品房销售面积、建筑施工面积3个自变量建立多元回归方程,对"十二五"时期北京市建筑垃圾产生量进行预测;并依据预测结果结合各区县发展定位,对建筑垃圾处置设施分布进行合理布点和处置设施建设规模研究.     

应用GM（1,1）模型预测我国艾滋病发病趋势

目的预测我国2010-2011年艾滋病发病流行趋势,为艾滋病防治工作提供参考依据。方法根据我国2005-2009年艾滋病发病人数资料,运用灰色系统GM（1,1）模型,预测我国2010-2011年艾滋病发病趋势。结果 2010-2011年我国艾滋病发病人数将大幅上升。预测模型精度为二级。结论国家管理机构应进一步完善艾滋病防控体系,重点加强艾滋病防治队伍建设及诊疗药品储备,以应对目前复杂的艾滋病疫情。     

Acute systemic MK‐801 induced functional uncoupling between hippocampal areas CA3 and CA1 with distant effect in the retrosplenial cortex

The hippocampus and retrosplenial cortex are integrated within a higher‐order cognitive circuit supporting relational (spatial, contextual, episodic) forms of learning and memory. Hippocampal place cells can coordinate multiple parallel representations in the same physical environment. Novel environment exploration triggers expression of immediate‐early genes (IEGs) Arc and Homer1a in spatial context‐specific ensembles of CA1 and CA3 neurons. Less is know about ensemble coding in the retrosplenial cortex (RSC), a region directly connected and functionally coupled to CA1. Hippocampal and retrosplenial damage is found in patients with schizophrenia alongside cognitive deficits affecting relational memory. Systemic administration of non‐competitive NMDAR antagonists such as MK‐801 is used to model psychosis in animals and humans. Acute systemic MK‐801 (0.15 mg/kg) impaired cognitive control in rats and ensemble code for spatial context in CA1. Here, we use expression of immediate‐early genes Arc and Homer 1a to examine ensemble coding in rat CA3 and RSC to test if the effect of MK‐801 extends upstream and downstream of CA1, respectively. Different rats explored the same context twice (A/A), explored two distinct contexts (A/B) or remained in their home cage (CC). In contrast to CA1, MK‐801 did not affect ensemble coding in CA3. Unlike CA3 and CA1, similarity of RSC ensembles active during exploration did not reflect change in spatial context, but MK‐801 (0.15 mg/kg) increased similarity in RSC ensembles active during spontaneous behavior in the home cage. The data provide support for MK‐801‐induced functional uncoupling between CA3 and CA1 and suggest that ensemble coding deficit may extend downstream of CA1. This deficit may reflect hyperassociative state in the cognitive circuit underlying cognitive disorganization in psychosis. © 2016 Wiley Periodicals, Inc.     

亚健康状态预警指标体系构建设想

亚健康状态在人群中具有较高的发生率,严重威胁着人们的健康,如何进行预警一直是人们关注的焦点.初步提出从亚健康状态的危险因素、临床表现、实验室监测指标、量表和问卷评价指标、中医证候等方面构建亚健康状态预警指标体系的设想.